Endobronchial valves placement for persistent air leaks in critically ill patients: chest tube removal and competing risk of death

Antonio Moretti, Luca Tabbì, Roberto Tonelli, Francesco Livrieri, Matteo Delle Vergini, Bianca Beghé, Enrico M. Clini and Alessandro Marchioni  |  July 28, 2026

This retrospective cohort study evaluated endobronchial valve placement for the management of persistent air leaks in critically ill patients requiring invasive mechanical ventilation or high-flow oxygen support. Endobronchial valve therapy was associated with rapid resolution of air leaks, with most patients achieving chest tube removal within two weeks and a median chest tube duration of 7.5 days after valve placement. The procedure demonstrated a favorable safety profile, with no life-threatening procedure-related complications reported. These findings suggest that endobronchial valves may be an effective chest drain management strategy for facilitating earlier chest tube removal in high-risk patients with alveolar-pleural or bronchiolar-pleural fistulas, although prospective studies are needed to confirm these results.

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