Optimal suction pressure on digital drainage systems for the management of postoperative air leaks together with IL-2 therapy: a retrospective cohort study

Ning Pang, Rongrong Fan, Mengqi Cao, Chaoqun Ma, Yingkun Liu, Lin Huang, Xiaohong Zhang, Yi Liu, Yanguo Liu  |  February 6, 2026

This retrospective study examined suction settings on digital drainage systems used with sclerosant interleukin-2 (IL‑2) pleurodesis for postoperative pulmonary air leaks. Low and medium suction pressures (-1 to –9 cmH₂O) were associated with significantly shorter air leak duration compared with higher suction (-9 to -12 cmH2O). High suction independently prolonged air leak, regardless of patient or surgical factors. These findings support using low‑to‑moderate digital suction when combining chest drainage with IL‑2 therapy to optimize air leak resolution.

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